Aquaporin 4 in traumatic brain injury: from molecular pathways to therapeutic target

E Dadgostar, S Rahimi, S Nikmanzar, S Nazemi… - Neurochemical …, 2022 - Springer
… -1 α (HIF-1 α) sirtuin 2, NF-κB, Malat1, nerve growth factor … shown to attenuate brain edema,
maintain blood–brain barrier … vascular endothelial growth factor (VEGF) upon brain injury [63]…

[HTML][HTML] Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

L Manni, G Conti, A Chiaretti… - Neural Regeneration …, 2023 - journals.lww.com
… with nerve growth factor, intranasally delivered to the brain … Moreover, NGF intranasal
treatment in AD transgenic mice … , attenuating, among others, the effects of proNGF on hp-tau. …

Acute intranasal treatment with nerve growth factor limits the onset of traumatic brain injury in young rats

L Manni, E Leotta, I Mollica, A Serafino… - British Journal of …, 2023 - Wiley Online Library
Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema
following traumatic brainIntranasal administration of nerve growth factor ameliorate beta-amyloid …

[HTML][HTML] Intranasal delivery of nerve growth factor in neurodegenerative diseases and neurotrauma

L Manni, G Conti, A Chiaretti, M Soligo - Frontiers in pharmacology, 2021 - frontiersin.org
… In astrocytes, NGF/p75NTR interaction attenuates the … of AD, using NGF brain-deprived
mice (AD11 mice), or multiple-… “Nerve growth factor in pediatric severe traumatic brain injury: …

[HTML][HTML] Immunohistochemical evaluation of aquaporin-4 and its correlation with CD68, IBA-1, HIF-1α, GFAP, and CD15 expressions in fatal traumatic brain injury

M Neri, A Frati, E Turillazzi, S Cantatore… - International journal of …, 2018 - mdpi.com
brain injury, brain edema almost always occurs and is heavily involved in the pathophysiology
of brain damage following traumatic injury… that vascular endothelial growth factors (VEGF), …

[HTML][HTML] Intranasal delivery: effects on the neuroimmune axes and treatment of neuroinflammation

EM Rhea, AF Logsdon, WA Banks, ME Erickson - Pharmaceutics, 2020 - mdpi.com
intranasal delivery of various compounds from growth factors to … Nerve growth factor (NGF)
is a neurotrophin that aids in … delivered intranasally and attenuated dopaminergic neuron loss …

Intranasal nerve growth factor administration improves cerebral functions in a child with severe traumatic brain injury: a case report

A Chiaretti, G Conti, B Falsini, D Buonsenso, M Crasti… - Brain Injury, 2017 - Taylor & Francis
… The intranasal delivery of NGF to the brain could represent a … Given intranasally in rats with
experimental TBI, NGF has … as attenuating amyloid β42 (Aβ42) deposits and brain oedema

[HTML][HTML] … fibroblast growth factor preserves blood-brain barrier integrity by activating the PI3K-Akt-Rac1 pathway and inhibiting RhoA following traumatic brain injury

F Wu, Z Chen, C Tang, J Zhang, L Cheng… - American journal of …, 2017 - ncbi.nlm.nih.gov
administration attenuated experimental TBI in mice, specifically by preserving endothelial
TJs and AJs, reducing vasogenic brain edema and attenuating neuronal … were intranasally

[HTML][HTML] Blood–brain barrier pathophysiology following traumatic brain injury

L Price, C Wilson, G Grant - … research in traumatic brain injury, 2016 - ncbi.nlm.nih.gov
hormone called nerve growth factor (NGF) is currently being studied for its potential to reduce
cellular cerebral edema in mice after … and attenuate this aspect of secondary brain injury. …

[HTML][HTML] Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of …

A Curatola, B Graglia, G Granata, G Conti, L Capossela… - Biology Direct, 2023 - Springer
… and aquaporins-4-induced oedema and lowered tau phosphorylation in injured rat brain. …
severe OHCA, such as attenuating amyloid β42 deposits and brain edema, inhibiting the …